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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-AICAR
AICAR

Chemical Structure : AICAR

CAS No.: 2627-69-2

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AICAR (Acadesine;AICA Riboside)

货号: PC-43519Not For Human Use, Lab Use Only.

AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.

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500 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.
AICAR inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes at 0.5 mM, inhibits insulin-stimulated glucose and reduces GLUT4 translocation in 3T3-L1 adipocytes.
AICAR down-regulates the insulin receptor expression in HepG2 cells.

物理化学性质&存储条件

分子量 258.23
分子式 C9H14N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

1H-Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-

参考文献

1. Sullivan JE, et al. FEBS Lett. 1994 Oct 10;353(1):33-6.

2. Young ME, et al. FEBS Lett. 1996 Mar 11;382(1-2):43-7.

3. Samari HR, et al. J Biol Chem. 1998 Sep 11;273(37):23758-63.

4. Ayasolla KR, et al. J Neuroinflammation. 2005 Sep 20;2:21.

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