AI-10-49

Chemical Structure : AI-10-49

CAS No.: 1256094-72-0

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货号: PC-45078Not For Human Use, Lab Use Only.

AI-10-49 is a potent (FRET IC50=260 nM) RUNX-CBFβ protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

AI-10-49 is a potent (FRET IC50=260 nM) RUNX-CBFβ protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.
AI-10-49 triggers selective cell death in primary inv(16) AML patient blasts.
AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice.

物理化学性质&存储条件

分子量	660.5233
分子式	C30H22F6N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-

参考文献

1. Illendula A, et al. Science. 2015 Feb 13;347(6223):779-84.

AI-10-49

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AI-10-49

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