AI-1 |CAS:75483-04-4 Probechem Biochemicals

Chemical Structure : AI-1

CAS No.: 75483-04-4

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AI-1 (Nrf2 activator AI-1)

货号: PC-62429Not For Human Use, Lab Use Only.

Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.

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生物&药学活性

Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.
Nrf2 activator AI-1 is an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

物理化学性质&存储条件

分子量	265.69
分子式	C13H12ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

参考文献

1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47.

2. Large M, et al. Strahlenther Onkol. 2015 Sep;191(9):742-9.

AI-1 (Nrf2 activator AI-1)

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物理化学性质&存储条件

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AI-1 (Nrf2 activator AI-1)

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