AGX51 | Id poteins inhibitor | Probechem Biochemicals

Chemical Structure : AGX51

CAS No.: 330834-54-3

加入收藏

AGX51 (AGX-51)

货号: PC-72578Not For Human Use, Lab Use Only.

AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5680	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
AGX51 induces ubiquitin-mediated degradation of Ids, cell growth arrest, and reduced viability.
AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization.
AGX51+aflibercept combination treatment worked better than aflibercept alone.
AGX51 as an anti-neovascular agent is likely due to its effects on blocking cell proliferation and vascular network disruption.

物理化学性质&存储条件

分子量	429.56
分子式	C28H31NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide

参考文献

1. Wojnarowicz PM, et al. Cell Rep. 2019 Oct 1;29(1):62-75.e7.

2. Wojnarowicz PM, et al. NPJ Breast Cancer. 2021 May 24;7(1):58.

AGX51 (AGX-51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AGX51 (AGX-51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.