AGT-5 | AHR ligand | Probechem Biochemicals

Chemical Structure : AGT-5

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AGT-5 (AGT5)

货号: PC-23187Not For Human Use, Lab Use Only.

AGT-5 is a indole-containing potential Aryl Hydrocarbon Receptor (AHR) fluorescent ligand, emits fluorescence in the near-infrared, shows AHR agonist activity.

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生物&药学活性

AGT-5 is a indole-containing potential Aryl Hydrocarbon Receptor (AHR) fluorescent ligand, emits fluorescence in the near-infrared, shows AHR agonist activity.
AGT-5 demonstrated the ability to foster anti-inflammatory regulatory T cells (Treg) while suppressing pro-inflammatory T helper (Th)17 cells in vitro.
AGT-5 actively induced Treg differentiation from naïve CD4+ cells, and promoted Treg proliferation, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression and interleukin-10 (IL-10) production.
AGT-5 oral administration showed no toxicity when applied to zebrafish embryos. AGT-5 significantly upregulated Treg while downregulating pro-inflammatory Th1 cells in the mesenteric lymph nodes in C57BL/6 mice.
AGT-5 ameliorates type 1 diabetes in mice through regulatory cell activation in the early phase of the disease.

物理化学性质&存储条件

分子量	335.37
分子式	C22H13N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[2-(1H-Indol-3-yl)ethenyl]-4H-1-benzopyran-4-ylidene]propanedinitrile

参考文献

1. Jonić N, et al. Molecules. (2024) 29:2988.

2. Jonić N, et al. Front Immunol. 2024 Sep 6;15:1454156.

AGT-5 (AGT5)

生物&药学活性

物理化学性质&存储条件

参考文献

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AGT-5 (AGT5)

生物&药学活性

物理化学性质&存储条件

参考文献

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