AGN 225660 | Prostaglandin Receptor antagonist | Probechem Biochemicals

Chemical Structure : AGN 225660

加入收藏

AGN 225660 (AGN225660)

货号: PC-20529Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively.
AGN 225660 dose-dependently inhibited LPS-induced RANTES and TNFα induced release of IL-8, MCP-1, and RANTES from human primary macrophages.
AGN 225660 increased LPS-induced MCP-1 secretion (up to 2-fold) from human monocyte-derived dendritic cells.
AGN 225660 exhibited good ocular bioavailability and was active in reducing ocular inflammation associated with phacoemulsification surgery, LPS, and arachidonic acid induced uveitis.

物理化学性质&存储条件

分子量	378.90
分子式	C20H27ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)CCC1=NN(CC2=CC(Cl)=CC=C2OCC(CC)CC)C(C)=C1

参考文献

1. David F Woodward, et al. ACS Pharmacol Transl Sci. 2020 Oct 26;3(6):1199-1210.

AGN 225660 (AGN225660)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AGN 225660 (AGN225660)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.