AGN194310 (VTP-194310) | pan-RAR inhibitor | Probechem Biochemicals

Chemical Structure : AGN194310

CAS No.: 229961-45-9

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AGN194310 (VTP-194310, VTP194310)

货号: PC-20205Not For Human Use, Lab Use Only.

AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM.

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生物&药学活性

AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM.
AGN194310 treatment led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis.
AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells.

物理化学性质&存储条件

分子量	424.56
分子式	C28H24O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-[4-(4-Ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]benzoic acid

参考文献

1. Hammond LA, et al. Br J Cancer. 2001 Aug 3;85(3):453-62.

2. Walkley CR, et al. Leukemia. 2002 Sep;16(9):1763-72.

AGN194310 (VTP-194310, VTP194310)

生物&药学活性

物理化学性质&存储条件

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AGN194310 (VTP-194310, VTP194310)

生物&药学活性

物理化学性质&存储条件

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