AGN-195183 |Cas:367273-07-2 Buy AGN-195183 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : AGN-195183

CAS No.: 367273-07-2

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AGN-195183 (VTP-195183;NRX-195183, IRX-5183)

货号: PC-70122Not For Human Use, Lab Use Only.

AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.
AGN-195183 significantly reduces albuminuria and normalizes blood pressure, lowers glomerulosclerosis index, glomerular cell and interstitial cell counts, and area of the interstitial space in nephritic rats.
AGN-195183 reduces renal damage in rats with established chronic glomerulonephritis.

物理化学性质&存储条件

分子量	437.86
分子式	C22H22ClF2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[(4-Chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-2,6-difluorobenzoic acid

参考文献

1. Schaier M, et al. J Mol Med (Berl). 2004 Feb;82(2):116-25.

AGN-195183 (VTP-195183;NRX-195183, IRX-5183)

生物&药学活性

物理化学性质&存储条件

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AGN-195183 (VTP-195183;NRX-195183, IRX-5183)

生物&药学活性

物理化学性质&存储条件

参考文献

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