AGK2 | SIRT2 inhibitor | Probechem Biochemicals

Chemical Structure : AGK2

CAS No.: 304896-28-4

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AGK2 (SIRT2 inhibitor AGK2)

货号: PC-38543Not For Human Use, Lab Use Only.

AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
AGK2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.

物理化学性质&存储条件

分子量	434.3
分子式	C23H13Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

参考文献

1. Outeiro TF, et al. Science. 2007 Jul 27;317(5837):516-9.

2. Kumar V, et al. Eur J Biochem. 2000 Jan;267(2):606-15.

3. Giammona LM, et al. Exp Hematol. 2009 Nov;37(11):1340-1352.e3.

AGK2 (SIRT2 inhibitor AGK2)

生物&药学活性

物理化学性质&存储条件

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AGK2 (SIRT2 inhibitor AGK2)

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物理化学性质&存储条件

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