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首页-小分子抑制剂&激动剂-Others-Other Targets-AGI-1067
AGI-1067

Chemical Structure : AGI-1067

CAS No.: 216167-82-7

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AGI-1067 (Succinobucol;AGI 1067;AGI1067)

货号: PC-61236Not For Human Use, Lab Use Only.

AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM) with concurrent antioxidant and lipid-modulating properties.

规格 价格 库存 数量
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM) with concurrent antioxidant and lipid-modulating properties.
AGI-1067 (Succinobucol) inhibits atherosclerosis in LDL receptor-deficient and apolipoprotein E-deficient mice.
AGI-1067 (Succinobucol) also reduces VCAM-1 and MCP-1 mRNA levels in lungs of LPS-stimulated mice.
AGI-1067 (Succinobucol) inhibits atherosclerosis not only via its lipid-lowering effects but also by having direct anti-inflammatory effects on the vessel wall.

物理化学性质&存储条件

分子量 616.916
分子式 C35H52O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-((1-((3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl)sulfanyl)-1-methylethyl)sulfanyl)-2,6-bis(1,1-dimethylethyl)phenoxy)-4-oxobutanoic acid

参考文献

1. Sundell CL, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23.

2. Meng CQ, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2545-8.

3. Tardif JC, et al. Circulation. 2003 Feb 4;107(4):552-8.

4. Kunsch C, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):820-9.

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