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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-AGH-192
AGH-192

Chemical Structure : AGH-192

CAS No.: 2173387-57-8

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AGH-192 (AGH192)

货号: PC-73304Not For Human Use, Lab Use Only.

AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.
    AGH-192 displays excellent water solubility, high selectivity over related CNS targets, high metabolic stability, oral bioavailability and low cytotoxicity.
    AGH-192 could crosses blood-brain barrier to a high extent.
    AGH-192 alleviates the symptoms of neuropathic pain in a mouse model.

    物理化学性质&存储条件

    分子量 355.155
    分子式 C13H11FIN3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(1-ethyl-1H-imidazol-5-yl)-5-iodo-4-fluoro-1H-indole

    参考文献

    1. Adam S Hogendorf, et al. Eur J Med Chem. 2019 May 15;170:261-275.

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