AG311 | Necrosis inducer | Probechem Biochemicals

Chemical Structure : AG311

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AG311 (AG-311, AG 311)

货号: PC-60649Not For Human Use, Lab Use Only.

AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization.

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生物&药学活性

AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization.
AG311 induces rapid necrosis in numerous cancer cell lines (IC50=5.9-29.3 uM), also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels.
AG311 does not increase apoptotic markers such as cleavage of PARP or caspase-3 and -7 activity, retards tumor growth and reduces lung metastases in breast cancer mouse models.

物理化学性质&存储条件

分子量	321.402
分子式	C17H15N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(4-methylphenyl)thio]-9H-pyrimido[4,5-b]indole-2,4-diamine

参考文献

1. Bastian A, et al. J Pharmacol Exp Ther. 2015 May;353(2):392-404.

2. Bastian A, et al. Cancer Lett. 2017 Mar 1;388:149-157.

AG311 (AG-311, AG 311)

生物&药学活性

物理化学性质&存储条件

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AG311 (AG-311, AG 311)

生物&药学活性

物理化学性质&存储条件

参考文献

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