欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Pyruvate Kinase-AG-946
AG-946

Chemical Structure : AG-946

CAS No.: 2283422-04-6

加入收藏

AG-946 (Tebapivat, AG946)

货号: PC-21605Not For Human Use, Lab Use Only.

AG-946 (Tebapivat, AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AG-946 (Tebapivat, AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively.
    AG-946 activates both WT PKR and a panel of prototypically unstable PKR mutants.
    AG-946 stabilizes PKR R510Q, an unstable mutant PKR enzyme, and preserves its catalytic activity under increasingly denaturing conditions.
    AG-946 demonstrated good activity in cell-based assays using purified RBCs, with an average AC50 for PKR activation of 35 nM and an average maximum percent PKR activation of 197%.
    AG-946 represents a new investigational PK activator with potential for low projected human drug load and long pharmacodynamic duration of action, suitable for clinical development in a broad range of hemolytic anemias and diseases characterized by dyserythropoiesis.

    物理化学性质&存储条件

    分子量 392.44
    分子式 C18H16N8OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((1H-pyrazol-3-yl)methyl)-6-((6-aminopyridin-2-yl)methyl)-4-methyl-4,6-dihydro-5H-thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one

    参考文献

    1. Liu T, et al. ChemMedChem. 2023 Dec 18:e202300559.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: