AG-7404 (V-7404) | Viral 3C protease inhibitor | Probechem Biochemicals

Chemical Structure : AG-7404

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AG-7404 (AG7404, V-7404)

货号: PC-20017Not For Human Use, Lab Use Only.

AG-7404 (V-7404) is a potent, irreversible inhibitor of picornaviral 3C protease, exhibits EC50 values of 80-674 nM against a large panel of programmatically important poliovirus strains.

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生物&药学活性

AG-7404 (V-7404) is a potent, irreversible inhibitor of picornaviral 3C protease, exhibits EC50 values of 80-674 nM against a large panel of programmatically important poliovirus strains.
AG-7404 was fully active against all Pocapavir (V-073)-resistant variants, with EC50 values ranging from 0.218 to 0.819 μM, compared to values of 0.202-0.407 μM for the V-073-susceptible parental strains.
AG-7404 demonstrated synergy effect with either V-073 or BTA798.

物理化学性质&存储条件

分子量	523.55
分子式	C26H29N5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (S,E)-4-((S)-2-(3-(5-methylisoxazole-3-carboxamido)-2-oxopyridin-1(2H)-yl)pent-4-ynamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

参考文献

1. Eric Rhoden, et al. Antiviral Res. 2013 May;98(2):186-91.

AG-7404 (AG7404, V-7404)

生物&药学活性

物理化学性质&存储条件

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AG-7404 (AG7404, V-7404)

生物&药学活性

物理化学性质&存储条件

参考文献

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