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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-AG-670
AG-670

Chemical Structure : AG-670

CAS No.: 313984-77-9

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AG-670 (AG670, PU02)

货号: PC-26483Not For Human Use, Lab Use Only.

AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.
AG-670 inhibits SCC-4 cell viability with IC50 of 41.8 uM.
AG-670 (10 uM) inhibits cellular oxygen consumption or in situ mitochondrial oxygen consumption in MCF 7 cells.

物理化学性质&存储条件

分子量 292.36
分子式 C16H12N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[(1-Naphthalenylmethyl)thio]-9H-purine

参考文献

1. Maloney B, et al. Pharmaceuticals (Basel). 2026 Mar 22;19(3):516.

2. Sarah M Trattnig, et al. J Biol Chem. 2012 Jul 20;287(30):25241-54.

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