AG-205 | PGRMC1 inhibitor | Probechem Biochemicals

Chemical Structure : AG-205

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AG-205 (AG205;AG 205)

货号: PC-70186Not For Human Use, Lab Use Only.

AG-205 is a small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.

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100 mg		Get quote

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生物&药学活性

AG-205 is a small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.
AG-205 decreases GLP-1-induced insulin secretion in β cells.
AG-205 inhibits cancer cell viability and cancer cell progression, acting preferentially on PGRMC1-expressing cells.

物理化学性质&存储条件

分子量	454.98
分子式	C22H23ClN6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)ethanone

参考文献

1. Privett BR, et al. Biochemistry. 2017 Jul 25;56(29):3840-3849.

2. Zhang M, et al. Mol Cell Proteomics. 2014 Nov;13(11):3049-62.

3. Mir SU, et al. Int J Cancer. 2012 Jul 15;131(2):E1-9.

4. Terzaghi L, et al. Cell Cycle. 2016 Aug 2;15(15):2019-32.

AG-205 (AG205;AG 205)

生物&药学活性

物理化学性质&存储条件

参考文献

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AG-205 (AG205;AG 205)

生物&药学活性

物理化学性质&存储条件

参考文献

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