AG-1296 |CAS:146535-11-7 Probechem Biochemicals

Chemical Structure : AG-1296

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AG-1296 (Tyrphostin AG 1296)

货号: PC-61281Not For Human Use, Lab Use Only.

A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells.

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生物&药学活性

A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells; potently inhibits signaling of human PDGF alpha- and beta-receptors, c-Kit but has no effect on autophosphorylation of KDR or on DNA synthesis induced by VEGF in porcine aortic endothelial cells.

物理化学性质&存储条件

分子量	266.3
分子式	C16H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy-2-phenylquinoxaline

参考文献

1. Kovalenko M, et al. Biochemistry. 1997 May 27;36(21):6260-9.

2. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.

3. Lipson KE, et al. J Pharmacol Exp Ther. 1998 May;285(2):844-52.

AG-1296 (Tyrphostin AG 1296)

生物&药学活性

物理化学性质&存储条件

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AG-1296 (Tyrphostin AG 1296)

生物&药学活性

物理化学性质&存储条件

参考文献

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