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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-AG-120-X
AG-120-X

Chemical Structure : AG-120-X

CAS No.: 1376918-61-4

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AG-120-X

货号: PC-21199Not For Human Use, Lab Use Only.

AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL.

物理化学性质&存储条件

分子量 427.89
分子式 C24H18ClN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(benzylamino)-6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide

参考文献

1. Abdel-Rahman SA, et al. RSC Med Chem. 2023 Aug 1;14(9):1767-1777.

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