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首页-小分子抑制剂&激动剂-Others-Other Targets-AF615
AF615

Chemical Structure : AF615

CAS No.: 122510-61-6

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AF615 (AF-615)

货号: PC-38705Not For Human Use, Lab Use Only.

AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.
    AF615 inhibits CDT1-Geminin protein-protein interaction, induces DNA damage and blocks DNA synthesis in cancer cells.
    AF615 reduces viability selectively in cancer cell lines.

    物理化学性质&存储条件

    分子量 267.31
    分子式 C10H13N5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N'-(morpholine-4-carbonothioyl)pyrazine-2-carbohydrazide

    参考文献

    1. Karantzelis N, et al. Front Pharmacol. 2022 Apr 25;13:860682.

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