AEP inhibitor 18

Chemical Structure : AEP inhibitor 18

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货号: PC-21548Not For Human Use, Lab Use Only.

AEP inhibitor 18 is a potent, selective, orally bioavailable, and brain penetrant inhibitor of asparagine endopeptidase (AEP) with IC50 of 7.8 nM.

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AEP inhibitor 18 is a potent, selective, orally bioavailable, and brain penetrant inhibitor of asparagine endopeptidase (AEP) with IC50 of 7.8 nM.

分子量	455.41
分子式	C21H21F4N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-Fluoro-N-[(1S)-1-(2-amino-2-oxo-ethyl)prop-2-ynyl]-1-[1-[4-(trifluoromethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

1. Krummenacher D, et al. J Med Chem. 2023 Dec 13. doi: 10.1021/acs.jmedchem.3c01804.