AEM2 |CAS:1005095-04-4 Probechem Biochemicals

Chemical Structure : AEM2

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AEM2 (SIRT2 inhibitor AEM2)

货号: PC-62391Not For Human Use, Lab Use Only.

SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.

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生物&药学活性

SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
AEM2 sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide.
AEM2 elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.

物理化学性质&存储条件

分子量	409.533
分子式	C27H27N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-phenyl-N-(pyridin-3-ylmethyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide

参考文献

1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.

AEM2 (SIRT2 inhibitor AEM2)

生物&药学活性

物理化学性质&存储条件

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AEM2 (SIRT2 inhibitor AEM2)

生物&药学活性

物理化学性质&存储条件

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