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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-AEM1
AEM1

Chemical Structure : AEM1

CAS No.: 1030123-90-0

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AEM1 (NRF2 inhibitor AEM1)

货号: PC-62392Not For Human Use, Lab Use Only.

NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC).

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10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC).
AEM1 broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2).
AEM1 sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo.

物理化学性质&存储条件

分子量 379.409
分子式 C20H14FN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

参考文献

1. Bollong MJ, et al. ACS Chem Biol. 2015 Oct 16;10(10):2193-8.

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