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首页-小分子抑制剂&激动剂-GPCR-mGluR-AE90015
AE90015

Chemical Structure : AE90015

CAS No.: 1206456-88-3

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AE90015 (AE-90015)

货号: PC-27666Not For Human Use, Lab Use Only.

AE90015 is a highly specific, effective negative allosteric modulator (NAM) for the human mGlu5 receptor (mGluR5), exhibiting an impressive affinity of 18.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AE90015 is a highly specific, effective negative allosteric modulator (NAM) for the human mGlu5 receptor (mGluR5), exhibiting an impressive affinity of 18.5 nM.
AE90015 shows no significant efficacy or affinity for other mGlu receptors, including mGlu1, mGlu2, mGlu3, mGlu4, and mGlu7.
AE90015 shows significant promise for treating Parkinson's disease.

物理化学性质&存储条件

分子量 391.48
分子式 C22H25N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-methyl-N-(3-(picolinamido)adamantan-1-yl)pyrazine-2-carboxamide

参考文献

1. Nasrallah C, et al. Cell Rep. 2021;36:109648.

2. Zou ZZ, et al. Molecules. 2024 Dec 4;29(23):5724.

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