ADX88178 | mGlu4 PAM | Probechem Biochemicals

Chemical Structure : ADX88178

CAS No.: 1235318-89-4

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ADX88178 (ADX 88178, ADX-88178)

货号: PC-60163Not For Human Use, Lab Use Only.

ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively.
ADX88178 displays highly selective for mGluR4 with minimal activities at other mGluRs.
ADX88178 reverses haloperidol-induced catalepsy, improves movement in rodent models of Parkinson's disease.

物理化学性质&存储条件

分子量	272.33
分子式	C12H12N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

参考文献

1. Le Poul E, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):167-77.

2. Kalinichev M, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.

3. Volpi C, et al. Neuropharmacology. 2016 Mar;102:59-71.

ADX88178 (ADX 88178, ADX-88178)

生物&药学活性

物理化学性质&存储条件

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ADX88178 (ADX 88178, ADX-88178)

生物&药学活性

物理化学性质&存储条件

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