ADX71743 | mGluR7 modulator | Probechem Biochemicals

Chemical Structure : ADX71743

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ADX71743 (ADX 71743)

货号: PC-20615Not For Human Use, Lab Use Only.

ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively.

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生物&药学活性

ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively.
ADX71743 induced a concentration-dependent rightward shift of the L-AP4 concentration-response curve without any impact on maximal efficacy of the agonist. no detectable activity (agonist or allosteric effects) in cell lines expressing hmGlu3, hmGlu4, rmGlu5, hmGlu6, and hmGlu8.
ADX71743 (50, 100, 150 mg/kg, s.c.) caused no impairment of locomotor activity in rats and mice or activity on rotarod in mice.
ADX71743 had an anxiolytic-like profile in the marble burying and elevated plus maze tests, dose-dependently reducing the number of buried marbles and increasing open arm exploration, respectively.

物理化学性质&存储条件

分子量	269.34
分子式	C17H19NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1CC(C2=CC=C(C)C=C2C)CC3=C1N=C(CC)O3

参考文献

1. Kalinichev M, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.

ADX71743 (ADX 71743)

生物&药学活性

物理化学性质&存储条件

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ADX71743 (ADX 71743)

生物&药学活性

物理化学性质&存储条件

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