ADX-47273 | mGlu5 PAM | Probechem Biochemicals

Chemical Structure : ADX-47273

CAS No.: 851881-60-2

加入收藏

ADX-47273 (ADX47273)

货号: PC-43360Not For Human Use, Lab Use Only.

ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3680	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM.
ADX-47273 causes a concentration-dependent increase in the response to 300 nM glutamate in primary astrocyte cultures with EC50 of 230 nM.
ADX-47273 displays no agonist, antagonist, or allosteric responses against rat mGlu1, human mGlu2 and mGlu4.
ADX-47273 increases ERK and CREBP phosphorylation in hippocampus and prefrontal cortex, demonstrates antipsychotic-like and procognitive activities in vivo models.

物理化学性质&存储条件

分子量	369.3647
分子式	C20H17F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Methanone, (4-fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-

参考文献

1. de Paulis T, et al. J Med Chem. 2006 Jun 1;49(11):3332-44.

2. Liu F, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39.

3. Engers DW, et al. ChemMedChem. 2009 Apr;4(4):505-11.

4. Rosenbrock H, et al. Eur J Pharmacol. 2010 Aug 10;639(1-3):40-6.

ADX-47273 (ADX47273)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ADX-47273 (ADX47273)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.