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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -ADTL-SA1215
ADTL-SA1215

Chemical Structure : ADTL-SA1215

CAS No.: 782387-91-1

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ADTL-SA1215 (ADTL-SA 1215)

货号: PC-21061Not For Human Use, Lab Use Only.

ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.
ADTL-SA1215 induces SIRT3-driven autophagy/mitophagy-associated cell death in MDA-MB-231 TNBC cells (IC50=2.19 uM).
ADTL-SA1215 exerts anti-tumor effect by targeting SIRT3-modulated autophagy in the MDA-MB-231 TNBC mouse xenograft model.

物理化学性质&存储条件

分子量 657.33
分子式 C26H29I2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-Butylbenzofuran-3-yl)(3,5-diiodo-4-(3-(pyrrolidin-1-yl)propoxy)phenyl)methanone

参考文献

1. Jin Zhang, et al. J Med Chem. 2021 Oct 14;64(19):14192-14216.

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