ADL5859 | DOR agonist | Probechem Biochemicals

Chemical Structure : ADL5859

CAS No.: 850173-95-4

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ADL5859 (ADL-5859, ADL 5859)

货号: PC-43352Not For Human Use, Lab Use Only.

ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM.
ADL5859 exhibits >1,000-fold selectivity for δ over µ and κ opioid receptors in both receptor binding and in vitro bioassays.
ADL5859 demonstrates analgesic and antidepressive effects in the rat and represent potential drug for chronic pain treatment, significantly reduces inflammatory and neuropathic pain, does not induce either hyperlocomotion or receptor internalization in vivo.

物理化学性质&存储条件

分子量	428.9517
分子式	C24H29ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)-, hydrochloride (1:1)

参考文献

1. Le Bourdonnec B, et al. J Med Chem. 2008 Oct 9;51(19):5893-6.

2. Nozaki C, et al. J Pharmacol Exp Ther. 2012 Sep;342(3):799-807.

3. Huang P, et al. Eur J Pharmacol. 2016 Jun 15;781:53-9.

ADL5859 (ADL-5859, ADL 5859)

生物&药学活性

物理化学性质&存储条件

参考文献

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ADL5859 (ADL-5859, ADL 5859)

生物&药学活性

物理化学性质&存储条件

参考文献

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