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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-ADL06
ADL06

Chemical Structure : ADL06

CAS No.:

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ADL06 (ADL-06)

货号: PC-23203Not For Human Use, Lab Use Only.

ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin.
ADL06 exhibited almost no activation ability for μOR and κOR.
ADL06 does not exhibit the gastrointestinal (GI) inhibition commonly observed with ADL5859 and SNC80.
ADL06 (i.p., 0.06 mmol/kg, 29 mg/kg) effectively alleviated visceral pain in chronic constriction injury (CCI)-induced neuropathic pain models.

物理化学性质&存储条件

分子量 448.61
分子式 C28H36N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1'-butyl-5-hydroxyspiro[chromene-2,4'-piperidin]-4-yl)-N,N-diethylbenzamide

参考文献

1. Cheng L, et al. Nat Commun. 2024 Sep 27;15(1):8284.

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