ADH-1 | N-cadherin inhibitor | Probechem Biochemicals

Chemical Structure : ADH-1

CAS No.: 229971-81-7

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ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2)

货号: PC-23769Not For Human Use, Lab Use Only.

ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2) is a cyclic pentapeptide N-cadherin antagonist, disrupts N-cadherin adhesion complexes and inhibits N-cadherin mediated cell adhesion.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2) is a cyclic pentapeptide N-cadherin antagonist, disrupts N-cadherin adhesion complexes and inhibits N-cadherin mediated cell adhesion.
ADH-1 inhibit the neurite outgrowth response stimulated by N-cadherin.
ADH-1 prevents collagen I-induced cell scattering and cell migration in pancreatic cancer cells.
ADH-1 induces apoptosis in a dose-dependent and N-cadherin-dependent manner.
ADH-1 50 mg/kg (i.p. 1× per day, 5× per week for 4 weeks) prevents tumor growth in a mouse model for pancreatic cancer.

物理化学性质&存储条件

分子量	570.68
分子式	C22H34N8O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R,7S,10S,13S,16R)-13-((1H-Imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide

参考文献

1. Williams E, et al. J Biol Chem. 2000 Feb 11;275(6):4007-12.

2. Pereira NL, et al. Sci Adv. 2024 Nov 29;10(48):eadp8872.

3. Ando K, et al. J Biol Chem. 2011 Mar 4;286(9):7619-28.

ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2)

生物&药学活性

物理化学性质&存储条件

参考文献

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