ADGRL1 inhibitor compound 2

Chemical Structure : ADGRL1 inhibitor compound 2

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货号: PC-26904Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ADGRL1 inhibitor compound 2 is a potential small molecule inhibitor of adhesion G protein-coupled receptor L1 (ADGRL1/Latrophilin-1), activates the GSK3β-STAT1 axis in CT26 cells in vitro, consistent with the knockdown of Adgrl1.
ADGRL1 inhibitor compound 2 targets the GAIN domain of ADGRL1.
ADGRL1 inhibitor compound 2 enhances the infiltration of CD8+ T cells and cDC1s and increased the expression of the activation markers CD69 on CD8+ T cells and CD86 on cDC1s.
ADGRL1 inhibitor compound 2 elicits robust antitumor immunity in CT26 syngeneic mouse models.

物理化学性质&存储条件

分子量	368.15
分子式	C16H9BrF3NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(1-bromo-2-naphthyl)oxy]-5-(trifluoromethyl) pyridine

参考文献

1. Cheng G, et al. Cell Rep. 2026 May 21;45(6):117409.