ADAMTS-5 inhibitor 12

Chemical Structure : ADAMTS-5 inhibitor 12

CAS No.: 929634-33-3

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货号: PC-23033Not For Human Use, Lab Use Only.

ADAMTS-5 inhibitor 12 is a potent selective ADAMTS-5 (aggrecanase-2) inhibitor with IC50 of 1.1 uM, >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

ADAMTS-5 inhibitor 12 is a potent selective ADAMTS-5 (aggrecanase-2) inhibitor with IC50 of 1.1 uM, >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

物理化学性质&存储条件

分子量	449.91
分子式	C16H11ClF3N3OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-((4-Chlorobenzyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one

参考文献

1. Gilbert AM, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92.