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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-ADAM9i
ADAM9i

Chemical Structure : ADAM9i

CAS No.: 860786-85-2

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ADAM9i (ADAM9 specific inhibitor)

货号: PC-21808Not For Human Use, Lab Use Only.

ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.

规格 价格 库存 数量
2 mg ￥2280 In stock
5 mg ￥3780 In stock
10 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM.
ADAM9i promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.

物理化学性质&存储条件

分子量 529.59
分子式 C26H19N5O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-((azanediylbis(thiazole-2,4-diyl))bis(ethane-2,1-diyl))bis(isoindoline-1,3-dione)

参考文献

1. Yu-Kai Huang, et al. Nat Cancer. 2024 Jan 24. doi: 10.1038/s43018-023-00720-x.

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