ADAM17 inhibitor SN-4

Chemical Structure : ADAM17 inhibitor SN-4

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货号: PC-72743Not For Human Use, Lab Use Only.

ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.
SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat.
SN-4 inhibited the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro, inhibited cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion.

物理化学性质&存储条件

分子量	508.714
分子式	C23H32N4O3S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(but-2-yn-1-yloxy)-N-((4-(dimethylamino)-6-(((2-mercaptoethyl)amino)methyl)pyridin-2-yl)methyl)-N-(2-mercaptoethyl)benzenesulfonamide

参考文献

1. Hiroshi Tateishi, et al. Chem Pharm Bull (Tokyo). 2021;69(11):1123-1130.