AD-9308 (AD9308) | ALDH2 activator | Probechem Biochemicals

Chemical Structure : AD-9308

CAS No.: 1804942-56-0

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AD-9308 (AD9308, AD 9308)

货号: PC-21249Not For Human Use, Lab Use Only.

AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg	￥8580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.
AD-5591 treatment increases the catalytic activity of recombinant wild-type and mutant human ALDH2 in vitro.
AD-9308 is rapidly converted to AD-5591 by esterase hydrolysis in vivo.
AD-9308 administration shows a favorable pharmacokinetic profile in mice when administered orally or intravenously with high bioavailability.
AD-9308 (20 mg/kg/day or 60 mg/kg/day, oral gavage for 20 weeks) lowered 4-HNE and attenuated diet-induced obesity, fatty liver, insulin resistance, and glucose intolerance in both WT and Aldh2 KI mice, ameliorated diet-induced insulin resistance and glucose intolerance.

物理化学性质&存储条件

分子量	537.63
分子式	C30H36FN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(3-((3-fluoro-4-methoxybenzyl)carbamoyl)-4-isobutoxyphenyl)pyridin-3-yl)methyl L-valinate

参考文献

1. Chang YC, et al. Nat Commun. 2023 Sep 25;14(1):5971.

AD-9308 (AD9308, AD 9308)

生物&药学活性

物理化学性质&存储条件

参考文献

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AD-9308 (AD9308, AD 9308)

生物&药学活性

物理化学性质&存储条件

参考文献

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