AD-5584 | ACSS2 inhibitor | Probechem Biochemicals

Chemical Structure : AD-5584

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AD-5584 (AD5584)

货号: PC-21663Not For Human Use, Lab Use Only.

AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.86 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.

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生物&药学活性

AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.86 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-5584 specifically binds ACSS2 (KD=188 uM) but not the mitochondrial isoform hACSS1.
AD-5584 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-5584 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.

物理化学性质&存储条件

分子量	414.91
分子式	C22H24ClFN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-(4-fluorophenyl)-N-methyl-2-(piperidin-1-yl)acetamide

参考文献

1. Emily Esquea, et al. bioRxiv. December 23, 2023.
2. Esquea EM, et al. Front Pharmacol. 2024 May 16;15:1394685.

AD-5584 (AD5584)

生物&药学活性

物理化学性质&存储条件

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AD-5584 (AD5584)

生物&药学活性

物理化学性质&存储条件

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