AD-35 phosphate |CAS:1531586-64-7 Probechem Biochemicals

Chemical Structure : AD-35 phosphate

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AD-35 phosphate (AD35 phosphate;AD 35 phosphate)

货号: PC-60065Not For Human Use, Lab Use Only.

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

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生物&药学活性

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

物理化学性质&存储条件

分子量	503.485
分子式	C24H27N3O3.H3O4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6'-[2-[1-(Pyridin-2-ylmethyl)piperidin-4-yl]ethyl]spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6’H)-one phosphate

参考文献

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

AD-35 phosphate (AD35 phosphate;AD 35 phosphate)

生物&药学活性

物理化学性质&存储条件

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AD-35 phosphate (AD35 phosphate;AD 35 phosphate)

生物&药学活性

物理化学性质&存储条件

参考文献

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