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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetylcholinesterase (AChE)-AD-35
AD-35

Chemical Structure : AD-35

CAS No.: 1531586-58-9

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AD-35 (AD 35;AD35)

货号: PC-60066Not For Human Use, Lab Use Only.

AD-35 is a donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AD-35 is a donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
    AD-35 markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

    物理化学性质&存储条件

    分子量 405.498
    分子式 C24H27N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one

    参考文献

    1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

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