ACT001 | NF-κB inhibitor, PKM2 activator | Probechem Biochemicals

Chemical Structure : ACT001

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ACT001 (Dimethylaminomicheliolide, DMAMCL)

货号: PC-23534Not For Human Use, Lab Use Only.

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生物&药学活性

ACT001 (dimethylaminomicheliolide, DMAMCL) is a guaianolide sesquiterpene lactone that targets lasminogen activator inhibitor-1 (PAI-1), also is a a nuclear factor-κB (NF-κB) signaling pathway inhibitor and PKM2 activator, effectively inhibits the proliferation of both tamoxifen-sensitive and tamoxifen-resistant cells.
ACT001 selectively activated PKM2 through covalent binding at residue cysteine 424 to promote tetramer formation.
ACT001 targets PAI-1 and inhibits glioma cell proliferation, invasion and metastasis through the PAI-1/PI3K/AKT pathway.
ACT001 can enhance the antitumour effects of cisplatin in vitro and in vivo.

物理化学性质&存储条件

分子量	279.38
分子式	C16H25NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Azuleno[4,5-b]furan-2(3H)-one, 3-[(dimethylamino)methyl]-3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-, (3R,3aS,9R,9aS,9bS)-

参考文献

1. Yu Q, et al. Eur J Pharmacol. 2024 May 15;971:176529.

2. Deng H, et al. Oncogenesis. 2023 Mar 30;12(1):19.

3. Jin XH, et al. J Cell Biochem. 2019 Feb;120(2):1386-1397.

4. Jaffar J, et al. Biomed Pharmacother. 2021 Jun;138:111471.

ACT001 (Dimethylaminomicheliolide, DMAMCL)

生物&药学活性

物理化学性质&存储条件

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ACT001 (Dimethylaminomicheliolide, DMAMCL)

生物&药学活性

物理化学性质&存储条件

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