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首页-小分子抑制剂&激动剂-GPCR-Orexin Receptor-ACT-539313
ACT-539313

Chemical Structure : ACT-539313

CAS No.: 1435480-40-2

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ACT-539313 (Nivasorexant, ACT539313)

货号: PC-21251Not For Human Use, Lab Use Only.

Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R.
Nivasorexant (ACT-539313) shows potential in the treatment of humans with binge-eating disorder.

物理化学性质&存储条件

分子量 429.48
分子式 C23H23N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[4-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl][(3R)-3-[[3-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-4-morpholinyl]methanone

参考文献

1. Berger B, et al. J Clin Pharmacol. 2020 Jul;60(7):931-941.

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