ACT-246475 | P2Y12 antagonist | Probechem Biochemicals

Chemical Structure : ACT-246475

加入收藏

ACT-246475 (Selatogrel, ACT246475, ACT 246475)

货号: PC-35577Not For Human Use, Lab Use Only.

ACT-246475 (ACT246475) is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ACT-246475 (ACT246475) is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM.
ACT-246475 displays no agonist binding activity against P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, and P2Y13 at 10 uM, to P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, no antagonistic activity on P2X1, P2X2, P2X3, P2X4, and P2X7 receptors, as well as a broad panel of receptors, transporters, and enzymes.
ACT-246475 inhibits plateletaggregation with IC50 of 8.0 nM in the light transmission aggregometry (LTA) assay.
ACT-246475 showes efficacy in the rat ferric chloride thrombosis model when administered intravenously.

物理化学性质&存储条件

分子量	618.628
分子式	C28H39N6O8P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic acid butyl ester

参考文献

1. Caroff E, et al. J Med Chem. 2015 Dec 10;58(23):9133-53.

2. Rey M, et al. Pharmacol Res Perspect. 2017 Oct;5(5).

3. Juif PE, et al. J Clin Pharmacol. 2018 Aug 8. doi: 10.1002/jcph.1296.

ACT-246475 (Selatogrel, ACT246475, ACT 246475)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ACT-246475 (Selatogrel, ACT246475, ACT 246475)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.