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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ACP1-06
ACP1-06

Chemical Structure : ACP1-06

CAS No.: 1371635-84-5

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ACP1-06 (ACP1b)

货号: PC-25351Not For Human Use, Lab Use Only.

ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

物理化学性质&存储条件

分子量 466.92
分子式 C18H18ClF3N2O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)propanamide

参考文献

1. Barghash MM, et al. Structure. 2025 Aug 5:S0969-2126(25)00261-8.

3. Leung E, et al. Chem Biol. 2011 Sep 23;18(9):1167-78.

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