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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ACP1-01
ACP1-01

Chemical Structure : ACP1-01

CAS No.: 1382489-31-7

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ACP1-01

货号: PC-25350Not For Human Use, Lab Use Only.

ACP1-01 is a small molecule activator of bacterial ClpP with EC50 of 3.4 μM and 2.6 μM for NmClpP and EcClpP respectively, noncovalently binds to ClpP C sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ACP1-01 is a small molecule activator of bacterial ClpP with EC50 of 3.4 μM and 2.6 μM for NmClpP and EcClpP respectively, noncovalently binds to ClpP C sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

物理化学性质&存储条件

分子量 500.47
分子式 C19H18F6N2O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methyl-N-(2-((2-(trifluoromethyl)phenyl)thio)ethyl)-2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)propanamide

参考文献

1. Barghash MM, et al. Structure. 2025 Aug 5:S0969-2126(25)00261-8.

2. Binepal G, et al. ACS Infect Dis. 2020 Dec 11;6(12):3224-3236.

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