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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ACOU085
ACOU085

Chemical Structure : ACOU085

CAS No.: 2243284-55-9

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ACOU085 (ACOU 085)

货号: PC-49796Not For Human Use, Lab Use Only.

ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range.
    ACOU085 reduces age-related outer hair cells (OHCs) loss in the senescence-accelerated mouse prone 8 (SAMP8) mice model.
    ACOU085 has potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function.

    物理化学性质&存储条件

    分子量 342.79
    分子式 C15H13ClF2N2OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(3,4-difluorophenyl)-1-(2-chloro-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)-1-methylurea

    参考文献

    1. Peixoto Pinheiro B, et al. Cell Death Dis. 2022 Jul 11;13(7):595.

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