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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-ACO1
ACO1

Chemical Structure : ACO1

CAS No.: 2065198-79-8

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ACO1 (Grp94 inhibitor ACO1)

货号: PC-62335Not For Human Use, Lab Use Only.

ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms.
    ACO1 exhibits a significant decrease in mutatnt myocilin I477N levels at 30 uM in tetracycline inducible HEK cells.
    ACO1 inhibits the migration of MDA-MB-231 and PC-3 MM-2 at 10 uM and 5 uM, respectively.

    物理化学性质&存储条件

    分子量 405.498
    分子式 C24H27N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(2-hydroxybenzyl)-1H-pyrrol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide

    参考文献

    1. Mishra SJ, et al. ACS Chem Biol. 2017 Jan 20;12(1):244-253.

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