ACKR3 agonist 27

Chemical Structure : ACKR3 agonist 27

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货号: PC-22930Not For Human Use, Lab Use Only.

ACKR3 agonist 27 is a potent, selective small molecule agonist of atypical chemokine receptor ACKR3 (CXCR7) with EC50 of 69 nM in β-arrestin recruitment assays, Emax=82%.

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生物&药学活性

ACKR3 agonist 27 is a potent, selective small molecule agonist of atypical chemokine receptor ACKR3 (CXCR7) with EC50 of 69 nM in β-arrestin recruitment assays, Emax=82%.
ACKR3 agonist 27 does not show agonistic activity against ACKR2, CXCR3, and CXCR4 at 10 uM.
ACKR3 agonist 27 demonstrates excellent P-selectin expression reduction up to 80%.
ACKR3 agonist 27 exhibits potent inhibitory effects on platelet aggregation (40% aggregation reduction).
ACKR3 agonist 27 exhibits metabolic stability, low cytotoxicity, and moderate kinetic solubility, rendering it a suitable tool compound for future in vitro and in vivo studies.

物理化学性质&存储条件

分子量	406.59
分子式	C25H30N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{3-[Benzyl(butyl)amino]propyl}-5-phenylthiophene-2-carboxamide

参考文献

1. Alp Bayrak, et al. J Med Chem. 2024 Aug 8. doi: 10.1021/acs.jmedchem.4c01371.

ACKR3 agonist 27

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ACKR3 agonist 27

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