ACI-16664

Chemical Structure : ACI-16664

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货号: PC-27215Not For Human Use, Lab Use Only.

ACI-16664 is an orally available brain penetrant tau aggregation inhibitor with IC50 of 0.27 uM, selectively binds and destabilizes pathological β sheets in tau aggregates.

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生物&药学活性

ACI-16664 is an orally available brain penetrant tau aggregation inhibitor with IC50 of 0.27 uM, selectively binds and destabilizes pathological β sheets in tau aggregates.
ACI-16664 eliminates pathological tau beta sheets, inhibits aggregation, and blocks tau seeding and toxicity in vitro.
ACI-16664 reduces preformed hTau 2N4R aggregates seeded by insoluble tau filaments from AD brains (AD tau PHFs; IC50 = 0.16 uM) instead of heparin.
ACI‐16664 both disrupts pre‐existing aggregates and also prevents the formation of new pathological tau β‐sheet structures.
ACI‐16664 binds to heparin‐induced hTau 2N4R aggregates with an apparent Kd of 48 ± 9 nM and has no detectable binding to hTau 2N4R.
ACI‐16664 inhibits tau seeding and toxicity in cortical neuron culturesmonomers.
ACI‐16664 inhibits the aggregation induced by insoluble and soluble AD brain tau seeds in rat cortical neurons.
ACI‐16664 broadly reduces pathological tau species, including soluble HMW aggregates and neurofibrillary tangles, and prevents neuronal loss, synaptic degeneration, and cortical atrophy in vivo.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Nicolas Preitner, et al. Alzheimers Dement. 2026 Jul;22(7):e71572.

ACI-16664

生物&药学活性

物理化学性质&存储条件

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ACI-16664

生物&药学活性

物理化学性质&存储条件

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