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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-ACHP hydrochloride
ACHP hydrochloride

Chemical Structure : ACHP hydrochloride

CAS No.: 406209-26-5

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ACHP hydrochloride (IKK-β (IKK2) inhibitor)

货号: PC-43364Not For Human Use, Lab Use Only.

ACHP hydrochloride is a potent and specific inhibitor for IKK-β (IKK2) with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM.

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5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ACHP hydrochloride is a potent and specific inhibitor for IKK-β (IKK2) with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM.
ACHP exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM).
ACHP inhibits TNFα-induced RANTES production in A549 cells with IC50 of 40 nM, inhibits NF-κB-dependent reporter gene activation in TNFα -activated HEK293 cells and PMA/calcium ionophore-activated Jurkat T cells.
ACHP demonstrates in vivo anti-inflammatory assays (1mg/kg, po) in arachidonic acid-induced ear edema model in mice.
ACHP also inhibits TNF-α-induced HIV-1 replication in latently infected cells with EC50 of 0.56 uM.

物理化学性质&存储条件

分子量 400.9018
分子式 C21H25ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinecarbonitrile, 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1)

参考文献

1. Victoriano AF, et al. Antimicrob Agents Chemother. 2006 Feb;50(2):547-55.

2. Murata T, et al. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22.

3. Sanda T, et al. Leukemia. 2006 Apr;20(4):590-8.

4. Mia MM, et al. J Cell Mol Med. 2015 Dec;19(12):2780-92.

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