ACHN-975 TFA

Chemical Structure : ACHN-975 TFA

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货号: PC-27726Not For Human Use, Lab Use Only.

ACHN-975 TFA (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

ACHN-975 TFA (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
ACHN-975 is potent against the P. aeruginosa isolates with MIC50 of 0.06 ug/mL and MIC90 of 0.25 ug/mL.
ACHN-975 demonstrated effectivity in a neutropenic mouse thigh model with P. aeruginosa ATCC 27853.

物理化学性质&存储条件

分子量	483.44
分子式	C22H24F3N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[(1S)-2-amino-1-[(hydroxyamino)carbonyl]-2-methylpropyl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]-1,3-butadiyn-1-yl]-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Cohen F, et al. ChemMedChem. 2019 Aug 20;14(16):1560-1572.

2. Krause KM, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00977-19.

3. Fan S, et al. Molecules. 2021 Mar 7;26(5):1451.

ACHN-975 TFA

生物&药学活性

物理化学性质&存储条件

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ACHN-975 TFA

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