ACHM-025 | DNA alkylating agent | Probechem Biochemicals

Chemical Structure : ACHM-025

CAS No.: 2377718-85-7

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ACHM-025 (ACHM025)

货号: PC-23372Not For Human Use, Lab Use Only.

ACHM-025 is a third generation AKR1C3-activated prodrug, selectively activates by AKR1C3 in the presence of NADPH to form the nitrogen mustard DNA alkylating agent.

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2 mg	￥2880	In stock
5 mg	￥4880	In stock
10 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

ACHM-025 is a third generation AKR1C3-activated prodrug, selectively activates by AKR1C3 in the presence of NADPH to form the nitrogen mustard DNA alkylating agent.
ACHM-025 showsa strong and significant correlation with basal AKR1C3 protein expression, shows selectivity for activation by the AKR1C3 isoform, compared to AKR1C1, AKR1C2 and AKR1C4 in HCT116 cells.
ACHM-025 has potent in vivo efficacy against T-ALL patient-derived xenografts (PDXs) and eradicated the disease in 7 PDXs.
ACHM-025 was significantly more effective than cyclophosphamide both as a single agent and when used in combination with cytarabine/6-mercaptopurine.
ACHM-025 ex vivo cytotoxicity shows a significant inverse correlation with AKR1C3 mRNA expression.

物理化学性质&存储条件

分子量	544.61
分子式	C17H28N4O10S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2-((4-methylpiperazin-1-yl)sulfonyl)-4-nitrophenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate

参考文献

1. Toscan CE, et al. Blood Cancer J. 2024 Nov 6;14(1):192.

ACHM-025 (ACHM025)

生物&药学活性

物理化学性质&存储条件

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ACHM-025 (ACHM025)

生物&药学活性

物理化学性质&存储条件

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